Beating Cardiomyocytes (heart cells) made from Induced Pluripotent Stem Cells (iPSC) which were derived from adult human cells that have been reprogrammed back into an embryonic-like pluripotent state.
Codding, S.J. and Trudeau, M.C. (2024) Photoinhibition of the hERG potassium channel PAS domain by ultraviolet light speeds channel closing. Biophysical Journal. May 24, 2024
Codding, S.J. and Trudeau, M.C. (2024) Photo-crosslinking hERG channels causes a U.V.-driven, state-dependent disruption of kinetics and voltage dependence of activation. Version 1. bioRxiv. Preprint. Jan 9, 2024 PMCID: PMC10802430
Johnson, A.. and Trudeau, M.C. (2024) Inhibition of hERG K channels by verapamil at physiological temperature: Implications for the CiPA Initiative. bioRxiv. Preprint.
Zheng, J., and Trudeau, M.C. (2023) Textbook of Ion Channels. Boca Raton, FL: CRC Press.
Johnson, A., Crawford, T.R., Trudeau, M.C. (2022) The N-linker region of hERG1a upregulates hERG1b potassium channels. J Biol Chem. 2022 Sep; 298(9): 102233. PMCID: PMC9428852
Harley, C.A., Bernardo-Seisdedos, G., Stevens-Sostre, W.A., Jones, D.K., Azevedo, M.M., Sampaio, P., Lorga-Gomes, M., Trudeau, M.C., Millet, O., Robertson, G.A., Morais-Cabral, J.H. (2021) Conformation-sensitive antibody reveals an altered cytosolic PAS/CNBh assembly during hERG channel gating. Proc Natl Acad Sci USA. 2021 Nov 2; 118(44): e2108796118. PMCID: PMC8612226
Codding, S. J., Johnson, A. A., Trudeau, M.C. (2020) Gating and regulation of KCNH (ERG, EAG, and ELK) channels by intracellular domains. Channels (Austin). 2020; 14(1): 294–309. PMCID: PMC7515569
Codding, S.J. and Trudeau, M.C. (2019) The hERG potassium channel intrinsic ligand regulates N- and C-terminal interaction and channel closure. J. Gen. Physiol. 151(4)478-488. PMCID: PMC6445578
Jones, D.K., Johnson, A., Roti Roti, E.C., Liu, F., Uelmen, R., Ayers, R.A., Baczko, I., Tester, D.J., Ackerman, M.J., Trudeau, M.C., Robertson, G.A. (2018) Localization and functional consequences of a direct interaction between TRIOBP-1 and hERG/KCNH2 proteins in the heart. J Cell Sci. Mar 22;131(6). PMCID: PMC5897710
McNally, B.A., Pendon, Z., Trudeau, M.C. (2017) hERG1a and hERG1b potassium channel subunits directly interact and preferentially form heteromeric channels. J Biol Chem. Dec 29;292(52):21548-21557. PMCID: PMC5766944
Liu, Q-N and Trudeau M.C. (2015) Eag Domains Regulate LQT Mutant hERG Channels in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes. PLoS ONE10 (4) e0123951. PMCID: PMC4414485.
Jones, D.K., Liu, F., Vaidyanathan, Eckhardt, L.L., Trudeau, M.C. and Robertson, G.A. (2014) hERG 1b is Critical for Human Cardiac Repolarization. Proceedings of the National Academy of Science, USA. 111(50) 18073-18077. PMCID: PMC4273358.
Gustina, A.S. and Trudeau, M.C. (2013) The eag domain regulates hERG channel inactivation via a direct interaction. The Journal of General Physiology, 141(2), 229-241. PMCID: PMC3557309.
Brelidze, T.I., Gianulis, E.G., DiMaio, F., Trudeau, M.C. and Zagotta, W.N. (2013) Structure of the C-terminal region of an ERG channel and functional implications. Proceedings of the National Academy of Sciences, USA. 110(28), 11648-11653. PMCID: PMC3710865
Gianulis E.C., Liu Q., Trudeau M.C. (2013) Direct interaction of eag domains and cyclic nucleotide-binding homology domains regulate deactivation gating in hERG channels. J Gen Physiol. 2013 Oct;142(4):351-366.PMCID: PMC3787778
Gustina, A.S. and Trudeau, M.C. (2013) The eag domain regulates hERG channel inactivation via a direct interaction.The Journal of General Physiology, 141(2), 229-241. PMCID: PMC3557309.
Brelidze, T.I., Gianulis, E.G., DiMaio, F., Trudeau, M.C. and Zagotta, W.N. (2013) Structure of the C-terminal region of an ERG channel and functional implications. Proceedings of the National Academy of Sciences, USA. 110(28), 11648-11653. PMCID: PMC3710865
Gustina, A.S. and Trudeau, M.C. (2012) hERG Potassium Channel Regulation by the N-terminal eag domain. Cellular Signalling.
Trudeau, M.C. (2012) Unlocking the mechanisms of HCN channel gating with locked-open and locked-closed channels.The Journal of General Physiology, 140(5), 457-461. PMCID: PMC3483117.
Gustina, A.S. and Trudeau, M.C. (2011) hERG potassium channel gating is mediated by N- and C-terminal region interactions. Journal of General Physiology, 137, 315-325. PMCID: PMC3047612
Gianulis, E.C. and Trudeau, M.C. (2011) Rescue of aberrant gating by a genetically-encoded PAS domain in several long QT syndrome mutant human ether á go-go related gene potassium channels. Journal of Biological Chemistry, 286, 22160-22169. PMCID: PMC3121360
Trudeau, M.C., Leung, L.M., Roti Roti, E., and Robertson, G.A. (2011) hERG1a N-terminal eag domain-containing polypeptides regulate homomeric hERG1b and heteromeric hERG1a/hERG1b channels: A possible mechanism for Long QT syndrome. Journal of General Physiology, 138(6), 581-592. PMCID: PMC3226966
Gustina, A.S. and Trudeau, M.C. (2009) A recombinant N-terminal domain fully restores deactivation gating in N-truncated and long QT syndrome mutant hERG potassium channels. Proceedings of the National Academy of Sciences. 106:13082-13087. PMCID: PMC2722319
Shepard P.D. and Trudeau, M.C. (2008) Emerging roles for ether á go-go related gene potassium channels in the brain. Journal of Physiology, Oct 15;586 (Pt 20):4785-6. PMCID: PMC2614064
Trudeau, M.C. and Zagotta, W.N. (2004) Dynamics of Ca2+-calmodulin dependent inhibition of rod cyclic nucleotide-gated channels measured by patch-clamp fluorometry. Journal of General Physiology. 124(3), 211-223. PMCID: PMC2233886
Trudeau, M.C. and Zagotta, W.N. (2003) Calcium/calmodulin modulation of olfactory and rod cyclic nucleotide-gated ion channels. Journal of Biological Chemistry. 278, 18705-18708.
Trudeau, M.C. and Zagotta, W.N. (2002) An intersubunit interaction regulates trafficking of rod cyclic nucleotide-gated channels and is disrupted in an inherited form of blindness. Neuron. 34, 197-207.
Trudeau, M.C. and Zagotta, W.N. (2002) Mechanism of calcium/calmodulin inhibition of rod cyclic nucleotide-gated channels. Proc. Natl. Acad. Sci. USA, 99(12), 8424-8429.
Trudeau, M.C., Titus, S.A., Branchaw, J.L., Ganetzky, B. and Robertson, G.A. (1999) Functional analysis of a mouse brain Elk-type K+ channel. Journal of Neuroscience. 19, 2906-2918.
Trudeau, M.C., Warmke, J.W., Ganetzky, B. and Robertson, G.A. (1995) HERG, a human inward rectifier in the voltage-gated potassium channel family. Science. 269, 92-95.